منابع مشابه
Comparison between rectal administration of diazepam in solution and intravenous administration for management of convulsive disorders in infants and children
In order to compare rectal and intravenous(IV) administration of diazepam for management of convulsions,a prospective cross-sectional case-control study was conducted on 94 convulsive infants and children referring to the Emergency department of the university hospital No.1 in Kerman.all children were randomly divided into two groups.the patients were matched with regard to the cause,type,durat...
متن کاملFormulation and evaluation of diazepam hydrogel for rectal administration.
Diazepam (DZP) has become a commonly used drug for treatment of acute repetitive epileptic seizures and febrile convulsions in children. Considering the advantages of rectal administration of DZP, the objective of our study was to formulate and evaluate rectal hydrogels containing DZP as a drug substance in combination with suitable co-solvents and preservatives. Prepared HPMC (hydroxypropyl me...
متن کاملEffects of the rectal administration of diazepam. Diazepam concentrations in children undergoing general anaesthesia.
Diazepam 1 mg/kg body weight was administered rectally to 14 children (11-22.5 kg) before minor surgery under general anaesthesia. Administration in solution (n = 7) resulted in a rapid increase in serum concentrations which were maintained for 8 h. Administration by suppository (n = 7) resulted in significantly lower serum concentrations at 10 and 20 min, but higher concentrations at 2 h. At o...
متن کاملRectal absorption of diazepam in epileptic children.
The absorption of diazepam after rectal administration was studied in children with epilepsy. When given as a solution, diazepam was rapidly absorbed and produced serum diazepam concentrations above 200 ng/ml within 10 minutes in most children. However, a commercial suppository formulation was absorbed slowly and cannot be recommended for urgent treatment of fits. There is a need in the UK for ...
متن کاملThe Situation of Suppression Seizures with Diazepam by Rectal Administration in China
Seizures are a manifestation of temporary brain dysfunction caused by abnormal discharge of brain neurons, Repeated; sustained seizures can cause irreversible brain damage. Rapid, reasonable choice on anticonvulsant drugs, Fast and effective measures on panic stop, Suppress of abnormal discharge, Prevention of convulsions again, All of which has an irreplaceable role on brain injury and recover...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1986
ISSN: 0007-0912
DOI: 10.1093/bja/58.3.361-a